Type XI collagen is a heterotrimer with the composition (1 alpha, 2 alpha, 3 alpha) retaining non-triple-helical domains.

Analyzing Collagen Alpha 1(XI) Using a Zebrafish Model System

Zebrafish (Danio rerio) are progressively becoming more popular as a model organism for research. The use of zebrafish is advantageous for several reasons. Zebrafish are small in size, exhibit high fecundity, rapidly generate, are transparent during development and are easily maintained in large numbers. Using zebrafish as a model organism, the aim of this project is to determine the function o...

COL 1 A 1 ( collagen , type I , alpha 1 )

Differential expression of collagen type V and XI alpha-1 in human ascending thoracic aortic aneurysms.

BACKGROUND The molecular mechanisms leading to ascending thoracic aortic aneurysms (ATAAs) remain unknown. We hypothesized that alterations in expression levels of specific fibrillar collagens occur during the aneurysmal process. METHODS Surgical samples from ascending aortas from patients with degenerative ATAAs were subdivided by aneurysm diameter: small, 5 to 6 cm; medium, 6 to 7 cm; and l...

Collagen Type XI Alpha 1 Expression in Intraductal Papillomas Predicts Malignant Recurrence

Despite the progress achieved in the treatment of breast cancer, there are still many unsolved clinical issues, being the diagnosis, prognosis, and treatment of papillary diseases, one of the highest challenges. Because of its unpredictable clinical behavior, treatment of intraductal papilloma has generated a great controversy. Even though considered as a benign lesion, it presents high rate of...

Alpha-helical coiled-coil oligomerization domains are almost ubiquitous in the collagen superfamily.

Alpha-helical coiled-coils are widely occurring protein oligomerization motifs. Here we show that most members of the collagen superfamily contain short, repeating heptad sequences typical of coiled coils. Such sequences are found at the N-terminal ends of the C-propeptide domains in all fibrillar procollagens. When fused C-terminal to a reporter molecule containing a collagen-like sequence tha...